Use caution when taking niacin in high doses. Niacin is a vasodilator, meaning it opens up the capillaries and allows increased blood flow to the skin. This causes the characteristic "niacin flush" with symptoms that can include reddening of the skin, increased warmth, skin tingling, and itching. It usually starts at the forehead and works its way down the body. The niacin flush is harmless and will pass, but this can be uncomfortable for some people. High dose niacin is not recommended for first-time niacin users. If you flush with low dose niacin, you can expect a more intense and prolonged flush if you jump to a high dosage without a gradual build up. To avoid an intense flush, start with a low dose niacin. Niacin (Vitamin B3) helps the body utilize proteins, fats and carbohydrates for energy, and also supports nerve and skin health. Niacin may help the body's efforts to lower cholesterol and supports digestive health.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.